Onderzoeker
Els Pardon
- Trefwoorden (Vrije Universiteit Brussel):Toegepaste biologische wetenschappen
- Disciplines (Flanders Institute for Biotechnology):(Bio)moleculaire modellering en design, Analytische biochemie, Medische biofysica
- Zie ook: Els Pardon (Vlaams Instituut voor Biotechnologie)
Affiliaties
- Structurele Biologie Brussel (Onderzoeksgroep)
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Vanaf1 jan 1998 → Heden - Toegepaste Biologische Wetenschappen (Departement)
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Vanaf8 apr 2019 → Heden - Steyaert Lab (Onderzoeksgroep)
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Vanaf1 jan 2017 → Heden - Cellulaire en Moleculaire Immunologie (Onderzoeksgroep)
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Vanaf1 feb 2003 → 31 dec 2006 - Toegepaste Biologische Wetenschappen (Departement)
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Vanaf1 jan 1999 → 20 okt 2022 - Ultrastructuur (Onderzoeksgroep)
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Vanaf1 jul 1998 → 1 jan 2010
Publicaties
11 - 20 van 108
- Snapshots of actin and tubulin folding inside the TRiC chaperonin(2022)
Auteurs: John M. Kelly, Dale Tranter, Els Pardon, Gamma Chi, Holger Kramer, Lotta Happonen, Kelly M Knee, Jay M Janz, Jan Steyaert, Christine Bulawa, et al.
Pagina's: 420-429 - Structure, substrate recognition and initiation of hyaluronan synthase(2022)
Auteurs: Finn P Maloney, Jeremi Kuklewicz, Robin A Corey, Yunchen Bi, Ruoya Ho, Lukasz Mateusiak, Els Pardon, Jan Steyaert, Phillip J Stansfeld, Jochen Zimmer
Pagina's: 195-201 - Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2(2022)
Auteurs: Ranjan Kumar Singh, Ahmed Soliman, Giambattista Guaitoli, Eliza Störmer, Felix von Zweydorf, Thomas Dal Maso, Asmaa Oun, Laura Van Rillaer, Sven H Schmidt, Deep Chatterjee, et al.
Pagina's: 1-12 - Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies(2022)
Auteurs: Jeremy R Keown, Zihan Zhu, Loïc Carrique, Haitian Fan, Alexander P Walker, Itziar Serna Martin, Els Pardon, Jan Steyaert, Ervin Fodor, Jonathan M Grimes
- Cryo-EM Structure of an Atypical Proton-Coupled Peptide Transporter(2022)
Auteurs: Maxime Killer, Giada Finocchio, Haydyn D T Mertens, Dmitri I Svergun, Els Pardon, Jan Steyaert, Christian Löw
Pagina's: 1-15 - Structure, mechanism, and inhibition of Hedgehog acyltransferase(2021)
Auteurs: Claire E Coupland, Sebastian A Andrei, T Bertie Ansell, Loic Carrique, Pramod Kumar, Lea Sefer, Rebekka A Schwab, Eamon F X Byrne, Els Pardon, Jan Steyaert, et al.
Pagina's: 5025-5038 - HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases(2021)
Auteurs: Manoj K Rathinaswamy, Kaelin D Fleming, Udit Dalwadi, Els Pardon, Noah J Harris, Calvin K Yip, Jan Steyaert, John E Burke
Pagina's: 1371-1381.e6 - Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins(2021)
Auteurs: Joël S Bloch, Somnath Mukherjee, Julia Kowal, Ekaterina V Filippova, Martina Niederer, Els Pardon, Jan Steyaert, Anthony A Kossiakoff, Kaspar P Locher
- Nanobody-aided crystallization of the transcription regulator PaaR2 from Escherichia coli O157:H7(2021)
Auteurs: Pieter De Bruyn, Marusa Prolic Kalinsek, Alexandra Vandervelde, Milan Malfait, Yann Sterckx, Frank Sobott, San Hadzi, Els Pardon, Jan Steyaert, Remy Loris
Pagina's: 374-384 - Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation(2021)
Auteurs: Linda Truebestein, Harald Hornegger, Dorothea Anrather, Markus Hartl, Kaelin D Fleming, Jordan T B Stariha, Els Pardon, Jan Steyaert, John E Burke, Thomas A Leonard
Patenten
1 - 10 van 10
- Cystic fibrosis transmembrane conductance regulator stabilizing agents (Inventor)
- Positive allosteric modulators of the calcium-sensing receptor (Inventor)
- Epitope tag for affinity-based applications (Inventor)
- Binding domains directed against gpcr: g protein complexes and uses derived thereof (Inventor)
- Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof (Inventor)
- Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof (Inventor)
- Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof (Inventor)
- Muscarinic acetylcholine receptor binding agents and uses thereof (Inventor)
- Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof (Inventor)
- Means and methods for selection of specific binders (Inventor)