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Onderzoeker
Christophe Pannecouque
- Disciplines:Microbiologie, Systeembiologie, Laboratoriumgeneeskunde
Affiliaties
- Laboratorium Virologie en Chemotherapie (Rega Instituut) (Afdeling)
Lid
Vanaf1 jul 2002 → Heden
Projecten
1 - 3 of 3
- Geautomatiseerd platform voor het verzamelen van gegevens over multiparameter levende ziekteverwekkers met een hoger of onbekend risico wat betreft bioveiligheidVanaf26 jun 2014 → 31 dec 2018Financiering: Hercules - Zware apparatuur
- Mechanistische studie van virus entry en replicatie. Een fundamentele benadering voor de ontwikkeling van nieuwe en specifieke antivirale chemotherapeutica.Vanaf1 jan 2010 → 31 dec 2014Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Identificatie van biomerkers en nieuwe therapeutische doelwitten in HTLV-1-geassocieerde pathologieën.Vanaf1 jan 2010 → 31 dec 2013Financiering: FWO Onderzoeksproject
Publicaties
31 - 40 van 399
- Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study(2023)
Auteurs: Erik De Clercq, Christophe Pannecouque
- Derivatives of 3′-Azidothymidine with 6-Cyanopyridone as Base or as Phosphoramidate Ester and their Antiretroviral Activity(2023)
Auteurs: Christophe Pannecouque, Graciela Andrei, Robert Snoeck
- Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs(2022)
Auteurs: Erik De Clercq, Christophe Pannecouque
Pagina's: 15608 - 15626 - Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators(2022)
Auteurs: Erik De Clercq, Christophe Pannecouque
- Discovery of novel 1,2,4-triazole phenylalanine derivatives targeting an unexplored region within the interprotomer pocket of the HIV capsid protein(2022)
Auteurs: Erik De Clercq, Christophe Pannecouque
Pagina's: 5975 - 5986 - Conformationally Locked Carbocyclic Nucleosides Built on a 4′- Hydroxymethyl-3′-hydroxybicyclo[4.1.0]heptane Template. Stereoselective Synthesis and Antiviral Activity(2022)
Auteurs: Christophe Pannecouque
Pagina's: 15166 - 15177 - Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators(2022)
Auteurs: Erik De Clercq, Christophe Pannecouque
- Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region(2022)
Auteurs: Erik De Clercq, Christophe Pannecouque
- Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors(2022)
Auteurs: Erik De Clercq, Christophe Pannecouque
- Discovery of novel biphenyl-substituted pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with promising oral bioavailability(2022)
Auteurs: Christophe Pannecouque, Erik De Clercq
Patenten
1 - 7 van 7
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral activity of novel bicyclic heterocycles (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION (Inventor)