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Onderzoeker
Christophe Pannecouque
- Disciplines:Microbiologie, Systeembiologie, Laboratoriumgeneeskunde
Affiliaties
- Laboratorium Virologie en Chemotherapie (Rega Instituut) (Afdeling)
Lid
Vanaf1 jul 2002 → Heden
Projecten
1 - 3 of 3
- Geautomatiseerd platform voor het verzamelen van gegevens over multiparameter levende ziekteverwekkers met een hoger of onbekend risico wat betreft bioveiligheidVanaf26 jun 2014 → 31 dec 2018Financiering: Hercules - Zware apparatuur
- Mechanistische studie van virus entry en replicatie. Een fundamentele benadering voor de ontwikkeling van nieuwe en specifieke antivirale chemotherapeutica.Vanaf1 jan 2010 → 31 dec 2014Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Identificatie van biomerkers en nieuwe therapeutische doelwitten in HTLV-1-geassocieerde pathologieën.Vanaf1 jan 2010 → 31 dec 2013Financiering: FWO Onderzoeksproject
Publicaties
11 - 20 van 399
- Development of novel HEPT analogs featuring significantly improved anti-resistance potency against HIV-1 through chemical space exploration of the tolerant region I(2023)
Auteurs: Christophe Pannecouque, Erik De Clercq
- Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles(2023)
Auteurs: Erik De Clercq, Christophe Pannecouque
- Comprehensive study of alkaloids from Scadoxus multiflorus by HPLC-PDA-SPE-NMR and evaluation of their anti-SARS-CoV-2 activity(2023)
Auteurs: Steven De Jonghe, Johan Neyts, Christophe Pannecouque
Pagina's: 156 - 162 - Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators(2023)
Auteurs: Erik De Clercq, Christophe Pannecouque
Pagina's: 1272 - 1295 - Picomolar inhibitor of reverse transcriptase featuring significantly improved metabolic stability(2023)
Auteurs: Christophe Pannecouque, Erik De Clercq
Pagina's: 3054 - 3066 - Discovery of novel sulfonamide substituted indolylarylsulfones as potent HIV-1 inhibitors with better safety profiles(2023)
Auteurs: Erik De Clercq, Christophe Pannecouque
Pagina's: 2747 - 2764 - Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles(2023)
Auteurs: Erik De Clercq, Christophe Pannecouque
Pagina's: 8643 - 8665 - Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors(2023)
Auteurs: Erik De Clercq, Christophe Pannecouque
- Fragment Hopping-Based Design of Novel Biphenyl-DAPY Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Improved Anti-Resistance Efficacy(2023)
Auteurs: Christophe Pannecouque, Erik De Clercq
Pagina's: 4755 - 4767 - Linker optimization of HEPT derivatives as potent non-nucleoside HIV-1 reverse transcriptase inhibitors: From S =O to CHOR(2023)
Auteurs: Christophe Pannecouque, Erik De Clercq
Patenten
1 - 7 van 7
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral activity of novel bicyclic heterocycles (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION (Inventor)