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Onderzoeker
Christophe Pannecouque
- Disciplines:Microbiologie, Systeembiologie, Laboratoriumgeneeskunde
Affiliaties
- Laboratorium Virologie en Chemotherapie (Rega Instituut) (Afdeling)
Lid
Vanaf1 jul 2002 → Heden
Projecten
1 - 3 of 3
- Geautomatiseerd platform voor het verzamelen van gegevens over multiparameter levende ziekteverwekkers met een hoger of onbekend risico wat betreft bioveiligheidVanaf26 jun 2014 → 31 dec 2018Financiering: Hercules - Zware apparatuur
- Mechanistische studie van virus entry en replicatie. Een fundamentele benadering voor de ontwikkeling van nieuwe en specifieke antivirale chemotherapeutica.Vanaf1 jan 2010 → 31 dec 2014Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
- Identificatie van biomerkers en nieuwe therapeutische doelwitten in HTLV-1-geassocieerde pathologieën.Vanaf1 jan 2010 → 31 dec 2013Financiering: FWO Onderzoeksproject
Publicaties
1 - 10 van 399
- Structure-based design of diarylpyrimidines and triarylpyrimidines as potent HIV-1 NNRTIs with improved metabolic stability and drug resistance profiles.(2024)
Auteurs: Christophe Pannecouque
Pagina's: e29502 - Structure-based design and optimization lead to the identification of novel dihydrothiopyrano[3,2-d]pyrimidine derivatives as potent HIV-1 inhibitors against drug-resistant variants.(2024)
Auteurs: Erik De Clercq, Christophe Pannecouque
Pagina's: 1257 - 1282 - In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket(2023)
Auteurs: Erik De Clercq, Christophe Pannecouque
- Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators(2023)
Auteurs: Erik De Clercq, Christophe Pannecouque
Pagina's: 16303 - 16329 - A new alkaloid from Pancratium maritimum - Structure elucidation using computer-assisted structure elucidation (CASE) and evaluation of cytotoxicity and anti-SARS-CoV-2 activity(2023)
Auteurs: Steven De Jonghe, Johan Neyts, Christophe Pannecouque
Pagina's: 1 - 7 - Structure-based design of novel heterocycle-substituted ATDP analogs as non-nucleoside reverse transcriptase inhibitors with improved selectivity and solubility(2023)
Auteurs: Christophe Pannecouque, Erik De Clercq
Pagina's: 4906 - 4917 - 4-Phenylcoumarin derivatives as new HIV-1 NNRTIs: Design, synthesis, biological activities, and computational studies(2023)
Auteurs: Christophe Pannecouque
- Structure-directed expansion of biphenyl-pyridone derivatives as potent non-nucleoside reverse transcriptase inhibitors with significantly improved potency and safety(2023)
Auteurs: Christophe Pannecouque
- 5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation(2023)
Auteurs: Erik De Clercq, Christophe Pannecouque
- Improving the anti-HIV-1 activity and solubility of poorly water-soluble DAPYs by heteroaromatic replacement strategy: From naphthalene-DAPYs to quinoline-DAPYs(2023)
Auteurs: Christophe Pannecouque, Erik De Clercq
Patenten
1 - 7 van 7
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral activity of novel bicyclic heterocycles (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Phosponate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production (Inventor)
- PHOSPHONATE NUCLEOSIDES USEFUL AS ACTIVE INGREDIENTS IN PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS, AND INTERMEDIATES FOR THEIR PRODUCTION (Inventor)