Onderzoeker
Christophe Pannecouque
- Trefwoorden:Geneeskunde
- Disciplines:Microbiologie, Systeembiologie, Laboratoriumgeneeskunde
Affiliaties
- Laboratorium Virologie en Chemotherapie (Rega Instituut) (Afdeling)
Lid
Vanaf1 jul 2002 → Heden
Projecten
1 - 3 of 3 results
- Geautomatiseerd platform voor het verzamelen van gegevens over multiparameter levende ziekteverwekkers met een hoger of onbekend risico wat betreft bioveiligheidVanaf26 jun 2014 → 31 dec 2018Financiering: Hercules - Zware apparatuur
- Identificatie van biomerkers en nieuwe therapeutische doelwitten in HTLV-1-geassocieerde pathologieën.Vanaf1 jan 2010 → 31 dec 2013Financiering: FWO Onderzoeksproject
- Mechanistische studie van virus entry en replicatie. Een fundamentele benadering voor de ontwikkeling van nieuwe en specifieke antivirale chemotherapeutica.Vanaf1 jan 2010 → 31 dec 2014Financiering: BOF - Geconcert. Onderzoeksacties vanaf 1994
Publicaties
1 - 10 of 295 results
- Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains.(2019)Tijdschrift: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 176
Auteurs: KaiJun Jin, YaLi Sang, Sheng Han, Erik De Clercq, Christophe Pannecouque, Ge Meng, FenEr Chen
Pagina's: 11 - 20 - Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors.(2019)Tijdschrift: European Journal of Medicinal ChemistryISSN: 0223-5234Volume: 182
Auteurs: Yali Sang, Sheng Han, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fener Chen
Pagina's: 111603 - Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains(2019)Tijdschrift: Bioorganic ChemistryISSN: 0045-2068Volume: 89
Auteurs: Yali Sang, Sheng Han, Shuwen Han, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang, Fener Chen
Aantal pagina's: 9 - Discovery of piperidine-substituted thiazolo[5,4-d] pyrimidine derivatives as potent and orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitors(2019)Tijdschrift: Communications ChemistryISSN: 2399-3669Volume: 2
Auteurs: Dongwei Kang, Tong Zhao, Zhao Wang, Da Feng, Heng Zhang, Boshi Huang, Gaochan Wu, Fenju Wei, Zhongxia Zhou, Lanlan Jing, et al.
Aantal pagina's: 8 - Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I(2019)Tijdschrift: Chemical Biology & Drug DesignISSN: 1747-0277Issue: 4Volume: 93
Auteurs: Dongwei Kang, Zhao Wang, Meng Chen, Da Feng, Gaochan Wu, Zhongxia Zhou, Lanlan Jing, Xiaofang Zuo, Xiangyi Jiang, Dirk Daelemans, et al.
Pagina's: 430 - 437Aantal pagina's: 8 - Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors(2019)Tijdschrift: Chemical Biology & Drug DesignISSN: 1747-0277Issue: 4Volume: 93
Auteurs: Ping Gao, Xueshun Wang, Lin Sun, Xiqiang Cheng, Vasanthanathan Poongavanam, Jacob Kongsted, Mar Alvarez, Joanna Luczkowiak, Christophe Pannecouque, Erik De Clercq, et al.
Pagina's: 582 - 589Aantal pagina's: 8 - Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus(2019)Tijdschrift: Organic & Biomolecular ChemistryISSN: 1477-0520Issue: 12Volume: 17
Auteurs: Zhongxia Zhou, Tao Liu, Gaochan Wu, Dongwei Kang, Zhipeng Fu, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Pagina's: 3202 - 3217Aantal pagina's: 16 - Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles(2019)Tijdschrift: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 4Volume: 62
Auteurs: Boshi Huang, Wenmin Chen, Tong Zhao, Zhenyu Li, Xiangyi Jiang, Tiziana Ginex, David Vilchez, Francisco Javier Luque, Dongwei Kang, Ping Gao, et al.
Pagina's: 2083 - 2098Aantal pagina's: 16 - Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties(2019)Tijdschrift: Journal of Medicinal ChemistryISSN: 0022-2623Issue: 3Volume: 62
Auteurs: Dongwei Kang, Heng Zhang, Zhao Wang, Tong Zhao, Tiziana Ginex, Francisco Javier Luque, Yang Yang, Gaochan Wu, Da Feng, Fenju Wei, et al.
Pagina's: 1484 - 1501Aantal pagina's: 18 - Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs(2019)Tijdschrift: Bioorganic & Medicinal ChemistryISSN: 0968-0896Issue: 3Volume: 27
Auteurs: Zhao Wang, Zhao Yu, Dongwei Kang, Jian Zhang, Ye Tian, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Pagina's: 447 - 456Aantal pagina's: 10