< Terug naar vorige pagina
Organisatie
Steyaert Lab
Research Group
Hoofdorganisatie:VIB-VUB Center for Structural Biology
Tijdsduur:1 jan 2017 → Heden
Organisatieprofiel:Exploiting nanobodies for drug discovery on difficult targets like GPCRs and on the engineering of nanobodies to be used in single particle cryo-EM and OMICs applications.
Trefwoorden:Molecular Biophysics, protein networks, Macromolecules, crystallography
Disciplines:Medicinale en biomoleculaire chemie, Biochemie en metabolisme, Biofysica
Huidige onderzoekers
1 - 10 of 22 results
- Jan Steyaert (Verantwoordelijke)
- Marjolijn Berghmans (Lid)
- Thomas Dal Maso (Lid)
- Phebe De Keyser (Lid)
- Babette Deckers (Lid)
- Baptiste Fischer (Lid)
- Galicia Christian (Lid)
- Danae Giakoumakis (Lid)
- Steven Janvier (Lid)
- Valentina Kalichuk (Lid)
Projecten
1 - 9 of 9
- Integrated Services for Infectious Disease Outbreak Research (ISIDORe)Vanaf1 feb 2022 → HedenFinanciering: Andere Eu-programma's en intiatieven
- VIB Grant for Steyaert Lab_Period:2022-01-01-2026-12-31Vanaf1 jan 2022 → HedenFinanciering: VOI - Projectmatig onderzoek
- GBA stabilization and activation through nanobodies and derived peptide mimetics in neuronal modelsVanaf1 sep 2021 → HedenFinanciering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- GBA1 stabilization through nanobodies : a versatile tool to improve wild type and mutant enzyme functionVanaf1 aug 2019 → 31 jan 2021Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Biochemical and structural characterization of LRRK2-specific nanobodiesVanaf27 jul 2019 → 26 jul 2021Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Application of novel nanobodies to existing LRRK2 biomarker assays for the segregation of affected patients in multiple cohorts of familial and idiopathic PDVanaf1 dec 2018 → 30 nov 2020Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- Conformation-specific nanobodies for biochemical, functional and structural characterization of LRRK2Vanaf15 jun 2017 → 14 jun 2019Financiering: Buitenl. stichtingen, fondsen e.d. met wet. oogmerk
- VIB Grant for Steyaert Lab_Period:2017-01-01-2021-12-31Vanaf1 jan 2017 → 31 dec 2021Financiering: VOI - Projectmatig onderzoek
- Releasing the full potential of Instruct to expand and consolidate infrastructure services for integrated structural life science researchVanaf1 jan 2017 → 31 dec 2020Financiering: Andere Eu-programma's en intiatieven
Publicaties
1 - 10 van 113
- Structural basis of purine nucleotide inhibition of human uncoupling protein 1.(2023)
Auteurs: Thomas Zögg, Els Pardon, Jan Steyaert
Pagina's: eadh4251 - Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies.(2020)
Auteurs: Margaux Leemans, Christian Galicia Diaz Santana, Egon Deyaert, Jone Paesmans, Els Pardon, Jan Steyaert, Wim Versées
Pagina's: 1203-1218 - Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1(2019)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 2404-2412 - Structure-Activity Relationship (SAR) Study of Spautin-1 to Entail the Discovery of Novel NEK4 Inhibitors.(2021)
Auteurs: Laila Maes, Wim Versées
Pagina's: 635 - Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor(2018)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 1996 - Structural basis of sodium-dependent bile salt uptake into the liver.(2022)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 1015-1020 - In vivo and in vitro characterizations of melibiose permease (MelB) conformation-dependent nanobodies reveal sugar-binding mechanisms.(2023)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 104967 - The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.(2019)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 975-982 - Structure of PINK1 in complex with its substrate ubiquitin(2017)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 51-56 - Generation and Characterization of Anti-VGLUT Nanobodies Acting as Inhibitors of Transport(2017)
Auteurs: Els Pardon, Jan Steyaert
Pagina's: 3962-3971