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Surface enhanced Raman scattering (SERS)-active bacterial detection by layer-by-layer (LbL) assembly all-nanoparticle microcapsules

Tijdschriftbijdrage - Tijdschriftartikel

Polymeric microcapsules composed by the Layer-by-Layer (LbL) approach have been used for various applications including drug delivery into cells and in vivo, conducting enzyme catalyzed reactions, performing sensoric functions. Typically, LbL-assembled microcapsules have been formulated via alternating deposition of positively and negatively charged polyelectrolytes onto sacrificial templates or so-called cores. In this work, we extend the LbL assembly to produce microcapsules solely based on nanoparticles instead of polymers. We have identified that 5 layers of nanoparticles is the minimum number of layers for a stable assembly of capsules on calcium carbonate templates. Subsequently, these capsules comprised of nanoparticles were applied as Surface Enhanced Raman Scattering (SERS) platform, where the nanoparticle-based shell of capsules is shown to enable SERS of both solutes and macromolecular structures such as bacterial cells.
Tijdschrift: COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN: 1873-4359
Volume: 650
Jaar van publicatie:2022
Toegankelijkheid:Open