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Octrooi

Process for the catalytic directed cleavage of amide-containing compounds

The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).
Octrooi-publicatienummer: WO2017046133
Jaar aanvraag: 2016
Jaar toekenning: 2018
Jaar van publicatie: 2017
Status: Aangevraagd
Technologiedomeinen: Organische fijne chemie
Gevalideerd voor IOF-sleutel: Ja
Toegewezen aan: Associatie Universiteit & Hogescholen Antwerpen