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Publicatie

Scarless excision of an insertion sequence restores capsule production and virulence in Acinetobacter baumannii

Tijdschriftbijdrage - Tijdschriftartikel

We identify a new mechanism mediating capsule production and virulence in the WHO and CDC priority ESKAPE pathogen Acinetobacter baumannii. Non-capsulated and avirulent bacteria can revert into a capsulated and virulent state upon scarless excision of an ISAba13 insertion sequence under stress conditions. Reversion events fully restore capsule production and in vivo virulence. This increases our knowledge about A. baumannii genome dynamics, and the regulation of capsule production, virulence and resistance.

Tijdschrift: ISME Journal (The)
ISSN: 1751-7362
Issue: 5
Volume: 16
Pagina's: 1473-1477
Jaar van publicatie:2022
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:10
Auteurs:International
Authors from:Government, Higher Education
Toegankelijkheid:Open