COMPOSITIONS AND METHODS FOR TREATING BIOFILMS

The present invention relates to novel methods and compositions comprising a compound, preferably perhexiline (maleate), drospirenone or toremiphene (citrate), which increases the susceptibility and sensitivity of biofi!ms to antifungal drugs such as amphotericin B and caspofungin. Accordingly, the present invention relates to use of said composition for the treatment or prevention of biofilms, particularly fungal or yeast biofilms, such as Candida biofilms, in a subject or on a surface or other medium susceptible to biofilm formation. Coating of medical devices, like implants and plastics with said compounds, in combination with conventional antifungal therapy for the treatment or prevention of biofilms is also contemplated.

Octrooi-publicatienummer: WO2014124504

Jaar aanvraag: 2014

Jaar toekenning: 2015

Jaar van publicatie: 2014

Status: Aangevraagd

Technologiedomeinen: Farmaceutische producten

Gevalideerd voor IOF-sleutel: Ja

Toegewezen aan: Associatie KULeuven