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An Image-based Musculoskeletal Modeling Platform For Simulation-based Evaluation Of Vertebral Motion In Adult Spinal Deformity

Boek - Dissertatie

Adult Spinal Deformity (ASD) has been identified in 68 % of the population older than 60 years. It is caused by asymmetric degeneration of the spinal joints, inducing varying degrees of trunk deformity, with an impact on the quality of life even larger than arthritis, lung disease, diabetes and heart failure. Despite advances in instrumentation, diagnostic tools and surgical techniques, up to 70% of spinal deformity patients continue to suffer from post-surgical complications. This is believed to be due to a lack of knowledge about how spinal deformity impacts the locomotor system during dynamic tasks through the current status of clinical evaluation and surgical planning in ASD. Certain research methods, such as instrumented motion capture and musculoskeletal modeling in combination with dynamic simulations of motion have clear potential to improve our insight into the relation between ASD and motor function. However, none of these methods currently allow routine analysis of spinal deformities, as methodologies for including the subject- specific spinal deformity as well as their effect on bone and muscular anatomy are not yet available. Consequently also the effect of these deformities on motion dynamics and muscle function has thus far not yet been extensively studied. Within the current project we will introduce advanced subject-specific musculoskeletal modeling, based on radiographic imaging, and motion simulation to advance the current understanding of ASD.
Jaar van publicatie:2021
Toegankelijkheid:Open