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A Novel Digital Care Management Platform to Monitor Clinical and Subclinical Disease Activity in Multiple Sclerosis

Tijdschriftbijdrage - Tijdschriftartikel

In multiple sclerosis (MS), the early detection of disease activity or progression is key to inform treatment changes and could be supported by digital tools. We present a novel CE-marked and FDA-cleared digital care management platform consisting of (1) a patient phone/web application and healthcare professional portal (icompanion) including validated symptom, disability, cognition, and fatigue patient-reported outcomes; and (2) clinical brain magnetic resonance imaging (MRI) quantifications (icobrain ms). We validate both tools using their ability to detect (sub)clinical disease activity (known-groups validity) and real-world data insights. Surveys showed that 95.6% of people with MS (PwMS) were interested in using an MS app, and 98.2% were interested in knowing about MRI changes. The icompanion measures of disability (p < 0.001) and symptoms (p = 0.005) and icobrain ms MRI parameters were sensitive to (sub)clinical differences between MS subtypes. icobrain ms also decreased intra- and inter-rater lesion count variability and increased sensitivity for detecting disease activity/progression from 24% to 76% compared to standard radiological reading. This evidence shows PwMS' interest, the digital care platform's potential to improve the detection of (sub)clinical disease activity and care management, and the feasibility of linking different digital tools into one overarching MS care pathway.

Tijdschrift: BRAIN SCIENCES
ISSN: 2076-3425
Issue: 9
Volume: 11
Jaar van publicatie:2021
Trefwoorden:digital health technology, eHealth, icobrain, icompanion, magnetic resonance imaging, mobile application, multiple sclerosis, patient reported outcomes
  • PubMed Central Id: PMC8469941
  • Scopus Id: 85114748873
  • DOI: https://doi.org/10.3390/brainsci11091171
  • ORCID: /0000-0002-2597-0383/work/101503690
  • ORCID: /0000-0003-2668-8061/work/101504867
  • WoS Id: 000699181400001
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:1
Auteurs:International
Authors from:Higher Education, Private
Toegankelijkheid:Open