Mathematical modeling of nuclei as pacemakers of cell cycle oscillations

In this project the student will theoretically analyze how cell division is spatially and temporally coordinated. Using computational modeling, the student will first uncover how multiple functional motifs (such as bistable switches) can optimally work together to create different desired cell responses in time. Second, the student will develop models to show how the cell cycle is dynamically coordinated in space. Special attention will be paid to studying how the spatial regulation of cell division is influenced by changes in its surroundings, such as differences in size and shape of the cells, as well as in its internal structure (i.e. cytoskeleton, nucleus, and centrosomes). The modeling efforts are expected to interact synergistically with experiments that are carried out by others in the lab.

Jaar van publicatie:2021

Toegankelijkheid:Open