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Publicatie
Synaptic proteostasis in Parkinson's disease
Tijdschriftbijdrage - Tijdschriftartikel
There are over 7 million people worldwide suffering from Parkinson's disease, and this number will double in the next decade. Causative mutations and risk variants in >20 genes that predominantly act at synapses have been linked to Parkinson's disease. Synaptic defects precede neuronal death. However, we are only now beginning to understand which molecular mechanisms contribute to this synaptic dysfunction. In this review, we discuss recent data demonstrating that Parkinson proteins act centrally to various protein quality control pathways at the synapse, and we argue that disturbed synaptic proteostasis is an early driver of neurodegeneration in Parkinson's disease.
Tijdschrift: Current Opinion in Neurobiology
ISSN: 0959-4388
Volume: 72
Pagina's: 72 - 79
Jaar van publicatie:2022
Toegankelijkheid:Open
- Zie ook: Synaptic proteostasis in Parkinson's disease.