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Identification of epitope-specific T cells in T-cell receptor repertoires

Boekbijdrage - Hoofdstuk

Recognition of cancer epitopes by T cells is fundamental for the activation of targeted antitumor responses. As such, the identification and study of epitope-specific T cells has been instrumental in our understanding of cancer immunology and the development of personalized immunotherapies. To facilitate the study of T-cell epitope specificity, we developed a prediction tool, TCRex, that can identify epitope-specific T-cell receptors (TCRs) directly from TCR repertoire data and perform epitope-specificity enrichment analyses. This chapter details the use of the TCRex web tool.
Boek: Bioinformatics for cancer immunotherapy : methods and protocols
Pagina's: 183 - 195
ISBN:978-1-0716-0326-0
Jaar van publicatie:2020
Trefwoorden:H1 Book chapter
Toegankelijkheid:Closed