Publicatie

Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge

Tijdschriftbijdrage - Tijdschriftartikel

Microglia respond as brain macrophages robustly to serum cytokine exposure but rapidly restore quiescence. Here, Shemer et al. establish the requirement of leukocyte-derived IL-10 to prevent fatal microglia hyperactivation and secretion of otherwise detrimental microglial TNF.

Tijdschrift: Immunity

ISSN: 1074-7613

Issue: 5

Volume: 53

Pagina's: 1033-1049

Jaar van publicatie:2020

Trefwoorden:Cx3cr1, IL-10, LPS, LTP, Microglia activation, TNF, conditional mutagenesis, sepsis, sickness behavior, tamoxifen

DOI: https://doi.org/10.1016/j.immuni.2020.09.018
PubMed Id: 33049219
Scopus Id: 85095412005
ORCID: /0000-0002-0826-4399/work/84575372
ORCID: /0000-0002-0412-6474/work/84575455
ORCID: /0000-0002-2260-2921/work/84576093
WoS Id: 000599348200014

CSS-citation score:2

Toegankelijkheid:Open

Zie ook: Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge
Zie ook: Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge.

Publicatie

Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge

Tijdschriftbijdrage - Tijdschriftartikel

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