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Assessment of dermal exposure to volatile organic compounds: method development, validation and application

Boek - Dissertatie

Exposure to noxious agents can be considered if there is contact of a hazardous material with the outer boundary of a subject: including respiratory system, digestive system and skin. Occupational exposure of workers plays an important role in the development of several diseases. Exposure to occupational agents, such as volatile organic compounds (VOCs), diisocyanates and polycyclic aromatic hydrocarbons (PAHs), is known to induce skin, respiratory and cardiovascular diseases and even cancer. In this project, we will address unanswered questions on the measurement of dermal exposure, by developing reliable, robust and sensitive quantitative methodologies for assessment of skin exposure to hazardous materials. This will allow to quantify actual skin exposure and estimate the contribution of skin exposure to whole body burden of chemicals exposure (lung and gastrointestinal). In this doctoral research project, we want to improve and to overcome current gaps in the assessment of dermal exposure via these steps: 1/ development of analytical methods for quantitative analysis of dermal exposure to volatile organic compounds (VOCs), diisocyanates and polycyclic aromatic hydrocarbon (PAHs); 2/ validation of dermal patches as reliable, robust and sensitive quantitative monitors, for the assessment of dermal exposure to VOCs, diisocyanates and PAHs; 3/ characterize the dermal exposure in addition to simultaneous assessment of the respiratory exposure (air monitoring) and the actual entrance into the body of selected target compounds (urinary determination of specific metabolites) in different work setting. The expected outcomes of this research project are validated methods and patches to assess dermal exposure to VOCs, diisocyanates and PAHs which can be implemented in routine occupational hygiene risk analysis.
Jaar van publicatie:2020
Toegankelijkheid:Closed