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Vitamin-guanosine monophosphate conjugates for in vitro transcription priming.

Tijdschriftbijdrage - Tijdschriftartikel

Expanding the catalytic repertoire of ribozymes to include vitamin synthesis requires efficient labelling of RNA with the substrate of interest, prior to in vitro selection. For this purpose, we rationally designed and synthesized six GMP-conjugates carrying a synthetic pre-thiamine or biotin precursor and investigated their transcription incorporation properties by T7 RNA polymerase.
Tijdschrift: Chemical Communications
ISSN: 1359-7345
Issue: 18
Volume: 56
Pagina's: 2787 - 2790
Jaar van publicatie:2020
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:2
CSS-citation score:1
Auteurs:International
Authors from:Higher Education
Toegankelijkheid:Open