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Type 3 IP3 receptors driving oncogenesis
Tijdschriftbijdrage - Tijdschrift Editorial
Type 3 Inositol 1,4,5-trisphosphate (IP3) receptors (IP3R3s) have been identified as anti-oncogenic channels by propelling pro-apoptotic Ca2+ signals to mitochondria. Yet, recent studies (Rezuchova et al, Cell Death Dis, 2019; Ueasilamongkol et al, Hepathology, 2019; Guerra et al, Gut, 2019) revealed that IP3R3 upregulation drives oncogenesis via ER-mitochondrial Ca2+ crosstalk, adding complexity to IP3R3's role in cancer.
Tijdschrift: Cell Calcium
ISSN: 0143-4160
Volume: 86
Jaar van publicatie:2020
Toegankelijkheid:Open