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Project
Maximalisatie van het anti-tumoraal potentieel van next-generation dendritische celvaccins door combinatie van interleukine-15 en in situ neutralisatie van geprogrammeerde celdoodliganden.
The GENERAL OBJECTIVE of this doctoral thesis is to develop a clinical grade highly immunogenic
antigen-specific anticancer vaccine. Aiming to unleash the full force of both adaptive and innate
anti-tumor immunity by DC vaccination, we hypothesize that suppression of the inhibitory
immune checkpoint molecules programmed death ligand (PD-L)1 and PD-L2 integrated into our
immunogenic IL-15 DCs will generate a superior cancer vaccine with unprecedented
immunostimulatory potential.
Datum:1 jan 2017 → 31 dec 2020
Trefwoorden:VACCINS TEGEN KANKER, TUMORVACCINATIE
Disciplines:Systeembiologie
Project type:Samenwerkingsproject