Microdosimetry at the CATANA 62 MeV proton beam with a sealed miniaturized TEPC

A new mini-TEPC with cylindrical sensitive volume of 0.9mm in diameter and height, and with external diameter of 2.7 mm, has been developed to work without gas flow. With such a mini counter we have measured the physical quality of the 62 MeV therapeutic proton beam of CATANA (Catania, Italy). Measurements were performed at six precise positions along the Spread-Out Bragg Peak (SOBP): 1.4, 19.4, 24.6, 29.0, 29.7 and 30.8 mm, corresponding to positions of clinical relevance (entrance, proximal, central, and distal-edge of the SOBP) or of high lineal energy transfer (LET) increment (distal-dose drop off). Without refilling the microdosimeter with new gas, the measurements were repeated at the same positions 4 months later, in order to study the stability of the response in sealed-mode operation. From the microdosimetric spectra the frequency-mean lineal energy yF and the dose-mean lineal energy yD were derived and compared with average LET values calculated by means of Geant4 simulations. The comparison points out, in particular, a good agreement between microdosimetric yD and the total dose-average LET_d, which is the average LET of the mixed radiation field, including the contribution by nuclear reactions.

Jaar van publicatie:2019

Trefwoorden:TEPC, Microdosimetry, Proton therapy, Proton RBE

BOF-keylabel:ja

IOF-keylabel:ja

BOF-publication weight:1

CSS-citation score:3

Auteurs:International

Authors from:Government, Higher Education, Private

Toegankelijkheid:Closed