< Terug naar vorige pagina

Publicatie

Critical Roles of Endogenous Glucocorticoids for Disease Tolerance in Malaria

Tijdschriftbijdrage - Tijdschriftartikel

During malaria, the hypothalamic-pituitary-adrenal (HPA) axis is activated and glucocorticoid (GC) levels are increased, but their essential roles have been largely overlooked. GCs are decisive for systemic regulation of vital processes such as immune responses, vascular function, and metabolism, which are crucial in malaria. Here, we introduce GCs in general, followed by their versatile roles for disease tolerance in malaria. A complementary comparison is provided with their role in sepsis. Finally, potential translational implications are considered. The failed clinical trials of dexamethasone against cerebral malaria in the past have diminished the interest in GCs in malaria. However, the issue of relative corticosteroid insufficiency has barely been explored in malaria patients, but may hold promise for a better understanding and treatment of specific malaria complications.
Tijdschrift: Trends in Parasitology
ISSN: 1471-4922
Issue: 11
Volume: 35
Pagina's: 918 - 930
Jaar van publicatie:2019
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:6
CSS-citation score:1
Authors from:Higher Education
Toegankelijkheid:Closed