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Molecular design opportunities presented by solvent-exposed regions of target proteins

Tijdschriftbijdrage - Tijdschriftartikel

Solvent-exposed regions, or solvent-filled pockets, within or adjacent to the ligand-binding sites of drug-target proteins provide opportunities for substantial modifications of existing small-molecular drug molecules without serious loss of activity. In this review, we present recent selected examples of exploitation of solvent-exposed regions of proteins in drug design and development from the recent medicinal-chemistry literature.
Tijdschrift: Medicinal Research Reviews
ISSN: 0198-6325
Issue: 6
Volume: 39
Pagina's: 2194 - 2238
Jaar van publicatie:2019
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:10
CSS-citation score:2
Auteurs:International
Authors from:Higher Education
Toegankelijkheid:Closed