< Terug naar vorige pagina
Publicatie
Beta cell replication is increased in donor organs from young patients following prolonged life support.
Tijdschriftbijdrage - Tijdschriftartikel
OBJECTIVE This study assesses beta-cell replication in human donor organs and examines possible influences of the preterminal clinical conditions.
RESEARCH DESIGN AND METHODS beta-Cell replication was quantified in a consecutive series of n = 363 human organ donors using double immunohistochemistry for Ki67 and insulin. Uni- and multivariate analysis was used to correlate replication levels to clinical donor characteristics and histopathologic findings.
RESULTS beta-Cell replication was virtually absent in most donors, with =90th percentile) of beta-cell replication, with the first three risk factors being independent predictors. Increased beta-cell replication was most often noted in relatively young donors (
CONCLUSION These results indicate that preterminal clinical conditions in (young) organ donors can lead to increased inflammatory infiltration of the pancreas and to increased beta-cell replication.
RESEARCH DESIGN AND METHODS beta-Cell replication was quantified in a consecutive series of n = 363 human organ donors using double immunohistochemistry for Ki67 and insulin. Uni- and multivariate analysis was used to correlate replication levels to clinical donor characteristics and histopathologic findings.
RESULTS beta-Cell replication was virtually absent in most donors, with =90th percentile) of beta-cell replication, with the first three risk factors being independent predictors. Increased beta-cell replication was most often noted in relatively young donors (
CONCLUSION These results indicate that preterminal clinical conditions in (young) organ donors can lead to increased inflammatory infiltration of the pancreas and to increased beta-cell replication.
Tijdschrift: Diabetes
ISSN: 0012-1797
Volume: 59
Pagina's: 1702-1708
Jaar van publicatie:2010
Trefwoorden:Beta cell
Toegankelijkheid:Open