Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway

Multiple myeloma (MM) is a malignant B cell disorder characterized by the accumulation of neoplastic plasma cells in the bone marrow (BM). One of the major characteristics of MM is the occurrence of bone lesions, caused by an imbalance between osteoblastic and osteoclastic function. Mesenchymal stem cells (MSCs) are a population of multipotent stem cells, which have the potential to differentiate into different mesenchymal tissues. Several previous studies indicated that BM-derived MSCs from MM patients showed an enhanced production of cytokines and a distinctive gene expression profile, as compared to their normal counterparts. Although osteoblastic function is decreased in advanced MM, regarding whether and at which level the differentiation of MSCs towards osteoblasts is impaired in this disease, the reports are not unanimous.

Jaar van publicatie:2012

Trefwoorden:myeloma