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Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain

Tijdschriftbijdrage - Tijdschriftartikel

VAR2CSA stands today as the leading vaccine candidate aiming to protect future pregnant women living in malaria endemic areas against the severe clinical outcomes of pregnancy associated malaria (PAM). The rational design of an efficient VAR2CSA-based vaccine relies on a profound understanding of the molecular interactions associated with P. falciparum infected erythrocyte sequestration in the placenta. Following immunization of a llama with the full-length VAR2CSA recombinant protein, we have expressed and ...
Tijdschrift: nature scientific reports
ISSN: 2045-2322
Volume: 4
Jaar van publicatie:2014
Trefwoorden:Malaria, Parasite immune evasion
CSS-citation score:1
Toegankelijkheid:Open