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Predictive power of screening for antibodies against IA-2 (beta) and zinc transporter-8 to select first-degree relatives of type 1 diabetic patients with risk of rapid progression to clinical onset of the disease. Implications for prevention trials.

Tijdschriftbijdrage - Tijdschriftartikel

AIMS/HYPOTHESIS: We investigated whether screening for insulinoma-associated protein (IA-2) beta (IA-2beta) autoantibodies (IA-2betaA) and zinc transporter-8 (ZnT8) autoantibodies (ZnT8A) improves identification of first-degree relatives of type 1 diabetic patients with a high 5-year disease risk, which to date has been based on assays for insulin autoantibodies (IAA), GAD autoantibodies (GADA) and IA-2 autoantibodies (IA-2A). METHODS: IA-2betaA and ZnT8A (using a ZnT8 carboxy-terminal hybrid construct, CW-CR, carrying 325Arg and 325Trp) were determined by radiobinding assay in 409 IAA(+), GADA(+) and/or IA-2A(+) siblings or offspring (
Tijdschrift: Diabetologia
ISSN: 0012-186X
Volume: 53
Pagina's: 517-524
Jaar van publicatie:2010
Trefwoorden:IA-2beta, zinc transporter-8, type 1 diabetes
  • ORCID: /0000-0002-6440-2485/work/61423557
  • ORCID: /0000-0002-8671-4527/work/61349429
  • ORCID: /0000-0002-9007-6177/work/60767596
  • ORCID: /0000-0002-9007-5203/work/58117061