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(Re)generating Human Beta Cells

Tijdschriftbijdrage - Tijdschriftartikel

Ondertitel:Status, Pitfalls, and Perspectives

Diabetes mellitus results from disturbed glucose homeostasis due to an absolute (type 1) or relative (type 2) deficiency of insulin, a peptide hormone almost exclusively produced by the beta cells of the endocrine pancreas in a tightly regulated manner. Current therapy only delays disease progression through insulin injection and/or oral medications that increase insulin secretion or sensitivity, decrease hepatic glucose production, or promote glucosuria. These drugs have turned diabetes into a chronic disease as they do not solve the underlying beta cell defects or entirely prevent the long-term complications of hyperglycemia. Beta cell replacement through islet transplantation is a more physiological therapeutic alternative but is severely hampered by donor shortage and immune rejection. A curative strategy should combine newer approaches to immunomodulation with beta cell replacement. Success of this approach depends on the development of practical methods for generating beta cells, either in vitro or in situ through beta cell replication or beta cell differentiation. This review provides an overview of human beta cell generation.

Tijdschrift: Physiological Reviews
ISSN: 0031-9333
Issue: 3
Volume: 98
Pagina's: 1143-1167
Jaar van publicatie:2018
Trefwoorden:Animals, Cell Culture Techniques, Homeostasis, Humans, Insulin-Secreting Cells/physiology, Regeneration
  • PubMed Central Id: PMC6088144
  • WoS Id: 000441185900003
  • ORCID: /0000-0003-1954-7375/work/61225762
  • ORCID: /0000-0002-0542-5708/work/60643879
  • ORCID: /0000-0001-8259-3329/work/54268398
  • Scopus Id: 85046753776
  • DOI: https://doi.org/10.1152/physrev.00034.2016
BOF-keylabel:ja
BOF-publication weight:10
CSS-citation score:1
Auteurs:Regional
Authors from:Hospital, Higher Education
Toegankelijkheid:Closed