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Harnessing FOXP3+ regulatory T cells for transplantation tolerance
Tijdschriftbijdrage - Tijdschriftartikel
Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.
Tijdschrift: J Clinical Investigation
ISSN: 0021-9738
Issue: 4
Volume: 124
Pagina's: 1439-1445
Trefwoorden:Animals, Epigenesis, Genetic, Forkhead Transcription Factors, Humans, Immunosuppression, Mice, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, Regulatory, Transplantation Tolerance