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The importance of HLA-G expression in embryos, trophoblast cells, and embryonic stem cells

Tijdschriftbijdrage - Tijdschriftartikel

The nonclassical HLA-G molecule is a trophoblast-specific molecule present in almost every pregnancy. It differs from classical HLA class I molecules by the low degree of allelic variants and the high diversity of protein structures. HLA-G is reported to be a tolerogenic molecule that acts on cells of both innate and adaptive immunity. At the maternal-fetal interface HLA-G seems to be responsible largely for the reprogramming of local maternal immune response. This review will focus on the HLA-G gene expression profile in pregnancy, in preimplantation embryos, and in human embryonic stem cells with emphasis on the structural diversity of the HLA-G protein and its potential functional and diagnostic implications
Tijdschrift: Cellular and Molecular Life Sciences : CMLS
ISSN: 1420-682X
Issue: 2011
Volume: 68
Pagina's: 341-352
Trefwoorden:HLA-G, HLA-G isoforms, Trophoblast cells, Embryonic stem cells, Embryo culture, Preimplantation embryo
  • ORCID: /0000-0001-8601-6561/work/61308282
  • Scopus Id: 79951558001