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Islet transplantation for type 1 diabetes

Tijdschriftbijdrage - Tijdschriftartikel

Ondertitel:So close and yet so far away

Over the past decades, tremendous efforts were made to establish pancreatic islet transplantation as a standard therapy for type 1 diabetes. Recent advances in islet transplantation have resulted in steady improvements in the five-year insulin independence rates for diabetic patients. Here, we review the key challenges encountered in the islet transplantation field which include islet source limitation, sub-optimal engraftment of islets, lack of oxygen and blood supply for transplanted islets, and immune rejection of islets. Additionally, we discuss possible solutions for these challenges.

Tijdschrift: Eur J Endocrinol
ISSN: 0804-4643
Issue: 5
Volume: 173
Pagina's: R165-R183
Jaar van publicatie:2015
Trefwoorden:beta cells, transplantation, diabetes, review
CSS-citation score:1
Toegankelijkheid:Open