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Publicatie
Maintenance of B cells during chronic murine Trypanosoma brucei gambiense infection.
Tijdschriftbijdrage - Tijdschriftartikel
African trypanosomosis is a debilitating parasitic disease occurring in large parts of sub-Saharan Africa. Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation-dependent apoptosis of splenic follicular B (FoB) cells and the destruction of B-cell memory against previously encountered pathogens. Here, we report that during murine infection with a chronic T. b. gambiense field isolate, FoB cells are retained. This coincided with reduced levels of IFN-γ and TNF-α during the acute phase of the infection. This result suggests that in chronic infections with low virulent parasites, less inflammation is elicited and consequently no FoB cell destruction occurs.
Tijdschrift: Parasite Immunol
ISSN: 0141-9838
Issue: 10
Volume: 38
Pagina's: 642-647
Jaar van publicatie:2016
CSS-citation score:1
Auteurs:International
Toegankelijkheid:Closed