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Publicatie
Biodegradable amphipathic peptide hydrogels as extended-release system for opioid peptides
Tijdschriftbijdrage - Tijdschriftartikel
Chronic pain is currently treated with opioids that offer unsatisfactory long-term analgesia and produce serious side effects. There is a clear need for alternative therapies. Herein, peptide-based hydrogels are used as extended-release drug delivery carriers. Two different formulations were developed: the drug is coformulated within the hydrogel; the drug is an integral part of the hydrogelator. Both strategies afford a prolonged and significant antinociception up to 72 h after subcutaneous administration in mice.
Tijdschrift: Journal of medicinal chemistry
ISSN: 0022-2623
Issue: 21
Volume: 61
Pagina's: 9784-9789
Jaar van publicatie:2018
BOF-keylabel:ja
BOF-publication weight:10
CSS-citation score:2
Auteurs:International
Authors from:Higher Education
Toegankelijkheid:Closed