Growth And Separation Of Crystals and Protein Aggregates in Acoustofluidics

Microfluidic devices offer a well-controlled environment for crystal nucleation and growth. Important parameters are mixing and the associated shear. Incomplete mixing results in a wide crystal size distribution and affect the morphology of the product. Bulk acoustic waves offer the possibility to quickly mix two liquid streams and to manipulate particles in the microfluidic channel. In this
contribution, fast mixing of two liquid streams by acoustic streaming is demonstrated. Miconazole nitrate crystals were grown in the presence of the acoustic field, and focused on the pressure node. Growth and focusing of amyloid fibrils in the microfluidic channel has also been demonstrated.

Jaar van publicatie:2019

Trefwoorden:crystals, protein aggregates, acoustofluidics

Toegankelijkheid:Open