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Synthesis and transformations of pyrrolo[1,2-a][1,3,5]-triazines

Tijdschriftbijdrage - Tijdschriftartikel

Pyrrolotriazines and related fused azaheterocycles have high potential for the synthesis of bioactive compounds, especially as a purine base isoster in carbon linked nucleosides. Although many structurally related compounds have already been synthesized and used in medicinal chemistry, pyrrolo[1,3,5]triazines have barely been described. The present work describes the synthesis of such heterocycles via condensation of 2-amino-3-ethoxycarbonylpyrrole with ethoxycarbonyliso(thio)cyanate. In a brief reactivity study of the obtained fused pyrroles, O- and S-alkylation, ester hydrolysis as well as regioselective bromination at the 6-position was demonstrated.
Tijdschrift: Tetrahedron Letters
ISSN: 0040-4039
Issue: 52
Volume: 59
Pagina's: 4537-4539
Jaar van publicatie:2018
Trefwoorden:Aminopyrrole, Bromination, Cyclocondensation, Nucleoside analogues, Pyrrolotriazines
BOF-keylabel:ja
BOF-publication weight:1
CSS-citation score:1
Auteurs:International
Authors from:Private, Higher Education
Toegankelijkheid:Open