Two new antiplasmodial flavonolignans from the leaves of Cecropia obtusifolia

Cecropia species are traditionally used in several Latin American countries to treat various diseases including malaria. A phytochemical investigation on the leaves of Cecropia obtusifolia Bertol (Urticaceae) afforded two new flavonolignans, i.e. ent-mururin A (1) and ent-vaccinin A (2). They were isolated by means of chromatographic techniques and elucidated based on their spectroscopic (NMR, MS and optical rotation) data, and were described as new isomers of mururin A and vaccinin A. Antiplasmodial evaluation revealed that 1 and 2 were moderately active in vitro against the chloroquine-resistant strain Plasmodium falciparum K1 (IC50 4.68 μM and 7.34 μM, respectively) without cytotoxic effects up to a concentration of 64.0 μM.

Jaar van publicatie:2019

Trefwoorden:A1 Journal article

BOF-keylabel:ja

BOF-publication weight:1

CSS-citation score:1

Auteurs:International

Authors from:Government

Toegankelijkheid:Open