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Psoriasis plays a wild CARD
Tijdschriftbijdrage - Tijdschrift Editorial
Rare autosomal mutations in CARD14 have previously been linked to psoriasis susceptibility in humans, but their pathogenic role had not been shown. Mellett et al. generated mice harboring the patient-derived gain-of-function Card14DE138 mutation and showed that hyperactivation of CARD14 alone is sufficient to induce immunopathogenic mechanisms that are responsible for psoriasis, which is driven by the IL-17/IL-23 axis.
Tijdschrift: JOURNAL OF INVESTIGATIVE DERMATOLOGY
ISSN: 1523-1747
Issue: 9
Volume: 138
Pagina's: 1903 - 1905
Jaar van publicatie:2018
Toegankelijkheid:Closed
- Zie ook: Psoriasis Plays a Wild CARD