Structural Similarities Between the Catalytic Domain of Threonine Deaminase and the Mammalian Serine Racemases

Comparison of a newly found enzyme with its structural homologues results in the prediction of probable regulatory binding sites. Since serine racemases are found to be promising targets for the treatment of disorders related to NMDAR dysfunction, the identification of the structural similarities between serine racemases and their structural homologues might provide structural insights for rational drug design. In this study, we aim to determine the structural similarities between the mammalian serine racemases and the bacterial biosynthetic threonine deaminase.

ISBN:9780769540580

Jaar van publicatie:2010