Digital quantification of Alzheimer's biomarker in biological samples

© 15CBMS-0001. This manuscript reports a digital ELISA integrated on a digital microfluidics (DMF) platform for the ultrasensitive detection of Alzheimer's disease (AD) biomarker Tau protein over a wide range of relevant physiological concentrations. High-affinity antibodies combined with optimal assay conditions led to astonishing limits of detection in the low-attomolar range in buffer samples, which constitutes the first step toward developing a blood test for AD diagnosis.

ISBN:9780979806483

Jaar van publicatie:2015

Toegankelijkheid:Closed