Comparative Analysis of HIV-1 and Murine Leukemia Virus Three-Dimensional Nuclear Distributions

Recent advances in fluorescence microscopy allow 3D analysis of HIV-1 pre-integration complexes in the nuclei of infected cells. To extend this investigation to gamma-retroviruses, we engineered a fluorescent Moloney murine leukemia virus (MLV) system, MLV-IN-EGFP. The comparative analysis between lentiviral (HIV-1) and gamma-retroviral (MLV) fluorescent viral complexes in the nuclei of infected cells revealed their different spatial distribution. This research tool has the potential to reveal new insight in the nuclear biology of these retroviruses.

Jaar van publicatie:2016

BOF-keylabel:ja

IOF-keylabel:ja

BOF-publication weight:2

CSS-citation score:1

Auteurs:International

Authors from:Higher Education

Toegankelijkheid:Closed