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Publicatie
LEDGINs inhibit late stage HIV-1 replication by modulating integrase multimerization in the virions
Tijdschriftbijdrage - Tijdschriftartikel
LEDGINs are novel allosteric HIV integrase (IN) inhibitors that target the lens epithelium-derived growth factor (LEDGF)/p75 binding pocket of IN. They block HIV-1 integration by abrogating the interaction between LEDGF/p75 and IN as well as by allosterically inhibiting the catalytic activity of IN.
Tijdschrift: Retrovirology
ISSN: 1742-4690
Issue: 1
Volume: 10
Pagina's: 57
Jaar van publicatie:2013
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:1
CSS-citation score:3
Auteurs:International
Authors from:Higher Education
Toegankelijkheid:Open