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Publicatie
Cell Junctions in Hippo Signaling
Tijdschriftbijdrage - Tijdschriftartikel
The Hippo signal transduction pathway is an important regulator of organ growth and cell differentiation, and its deregulation contributes to the development of cancer. The activity of the Hippo pathway is strongly dependent on cell junctions, cellular architecture, and the mechanical properties of the microenvironment. In this review, we discuss recent advances in our understanding of how cell junctions transduce signals from the microenvironment and control the activity of the Hippo pathway. We also discuss how these mechanisms may control organ growth during development and regeneration, and how defects in them deregulate Hippo signaling in cancer cells.
Tijdschrift: Cold Spring Harbor perspectives in biology
ISSN: 1943-0264
Issue: 5
Volume: 10
Jaar van publicatie:2018
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:3
CSS-citation score:2
Authors from:Higher Education
- Zie ook: Cell Junctions in Hippo Signaling