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Enhanced endogenous bone morphogenetic protein signaling protects against bleomycin induced pulmonary fibrosis

Tijdschriftbijdrage - Tijdschriftartikel

Effective treatments for fibrotic diseases such as idiopathic pulmonary fibrosis are largely lacking. Transforming growth factor beta (TGFβ) plays a central role in the pathophysiology of fibrosis. We hypothesized that bone morphogenetic proteins (BMP), another family within the TGFβ superfamily of growth factors, modulate fibrogenesis driven by TGFβ. We therefore studied the role of endogenous BMP signaling in bleomycin induced lung fibrosis.
Tijdschrift: Respiratory Research
ISSN: 1465-993X
Issue: 1
Volume: 16
Jaar van publicatie:2015
BOF-keylabel:ja
IOF-keylabel:ja
BOF-publication weight:1
CSS-citation score:2
Authors from:Higher Education
Toegankelijkheid:Open