Mass transport during intraperitoneal chemotherapy in tumor nodule: a computational model

The intraperitoneal (IP) administration of chemotherapy is an alternative treatment to conventional chemotherapy for patients with peritoneal carcinomatosis. During IP therapy, the peritoneal membrane and embedded tumor nodules are brought into direct contact with the cytotoxic solution, aiming for a higher intratumor drug concentration. Currently, there is no widespread use of this promising therapy because of the limited drug penetration depth in the tumor tissue. To study the influence of different parameters governing the drug transport during IP chemotherapy, a 3D computational fluid dynamics (CFD) model was created to represent a single tumor nodule (isotropic porous medium) and its simplified vascular network. A parameter study was performed in which the drug diffusivity, tissue permeability and mass fraction of chemo at the tumor edge were varied. The model is able to simulate the response of both local and systemic drug concentration profiles to changes in different drug and tissue properties during IP chemotherapy. This approach leads to more insight in the therapeutic relevance of the different parameters.

Jaar van publicatie:2014

Toegankelijkheid:Closed