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Biomimetic drug development: towards the oxidative variation of polycyclic carbon skeletons

Boekbijdrage - Boekabstract Conferentiebijdrage

In this work we report an efficient synthetic strategy, inspired by the biogenesis of biologically active terpenoid natural products. Through the use of a novel (4+3)U+2013 cycloaddition and subsequent oxidative variation of the polycyclic reaction products, incorporating a fused furan and seven membered ring, a small collection of compounds with interesting U+201Cdrug leadU+201D-like structures and properties was prepared. These results show that a library of U+201CmetabolitesU+201D of unnatural polycyclic scaffolds could be prepared in a very short amount of time, which might be very useful as chemical probes for studying various biological processes and for use in various drug discovery screening assays.
Boek: Book of abstracts : 18th Sigma-Aldrich organic synthesis meeting
Aantal pagina's: 1
Jaar van publicatie:2014