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Project

Prospectieve longitudinale MRI en PET studies en epileptogenese en hersenplasticiteit in epilepsie met behulp van [18F]fluorodeoxyglucose (FDG), [18F]flumazenil (FMZ), en [18F]MK-9470 in kleine proefdieren met epilepsie.

The aim of the project is to investigate epileptogenesis and brain plasticity due to seizures using two complementary animal models that closely represent temporal lobe epilepsy in humans, i.e. the amygdala kindling model and the status epilepticus model. We intend to characterize several neurobiological processes during epileptogenesis and chronic epilepsy in these two animal models using video-EEG monitoring, and in vivo structural (MRI and DTI) and functional (PET) imaging, which will lead to more insight into the pathophysiology of epilepsy. We plan - to study changes in GABAA-receptor expression ([18F]-flumazenil, [18F]-FMZ) and the cannabinoid type 1 receptor (CB1R, [18F]-MK-9470) expression during epileptogenesis, - to investigate whether these PET-ligands can be used as markers for the ictal onset zone, seizure propagation pathways, surround inhibition or functional deficit zone, - to study the temporal and permanent effects of repeated seizures on [18F]-FMZ-, [18F]-MK-9470- and FDG-binding in the brain, and brain structure - to find biomarkers for the process of epileptogenesis, which will facilitate the development of antiepileptogenic drugs. The studies will be performed in the MOSAIC (Molecular Small Animal Imaging Center).
Datum:1 jan 2009 →  31 dec 2014
Trefwoorden:Epileptology