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Project

iMAGiNe.

This project aims to develop magnetic nanoparticle crystals with physicochemical properties tailored for in vivo diagnostic MR imaging and cell tracking following the ex-vivo labeling of cells. Desirable properties from such nanoparticles are stronger signal intensity using a smaller number of particles, better and more specific cellular uptake, the potential to be utilized for quantification and non-toxicity, improved specificity and stability in time. Such requirements can be met by tuning the magnetic composition, the physical size and geometry, the chemical and biofunctional coatings, polymeric/silica based core-shell thickness and/or lipidic coating techniques. Such nanoparticle development effort also requires co-development of analytical techniques to assess the properties of these novel materials. To reach this aim, we need to develop diagnostic magnetic nanoparticle imaging/tracking methods to reach high sensitivity and specificity. Whereas current MRI diagnostic imaging techniques are optimized to provide maximal tissue contrast, the same instruments can be tuned to be sensitive towards information on the magnetic particles. Such imaging method can be used for sensitive stem cell tracking.
Datum:1 feb 2009 →  31 jul 2012
Trefwoorden:Magnetic nanoparticle, Therapeutic cells