PDZ-eiwitten op het kruispunt van lipide en peptide signaaltransductie.

The project concerns fundamental aspects of how PDZ proteins integrate phosphoinositide and peptide signaling and the prevalence of such interactions. The methods comprise a screen, microscopy, SPR, spectrofluorimetry and mutagenesis.

Trefwoorden:Membrane, Lipids, PtdlnsPs, Phosphoinositide, PDZ