Onderzoeker
Jean-Marc Taymans
- Trefwoorden:Biomedische wetenschappen
Affiliaties
- Onderzoeksgroep voor Neurobiologie en Gentherapie (Afdeling)
Lid
Vanaf1 okt 2005 → 30 sep 2014
Projecten
1 - 3 of 3
- Study of the cellular signaling processes of the Parkinsons disease protein LRRK2.Vanaf1 apr 2012 → 31 mrt 2014Financiering: Andere fed. openbare en parastatale instellingen.
- Het ontrafelen van de cellulaire signalering van LRRK2 neurodegeneratie in de ziekte van Parkinson.Vanaf1 jan 2012 → 31 dec 2014Financiering: FWO Krediet aan Navorser
- Structurele en functionele studie van de centrale GTPase/kinase katalytische kern van LRRK2, een eiwit gelinkt aan de ziekte van Parkinson.Vanaf1 jan 2009 → 31 dec 2014Financiering: FWO Onderzoeksproject (incl. WEAVE projecten)
Publicaties
1 - 10 van 32
- Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate(2015)
Auteurs: Lauran Reyniers, Evy Lobbestael, Jean-Marc Taymans, Veerle Baekelandt
Pagina's: 2980 - 2992 - Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate(2015)
Auteurs: Petranka Krumova, Lauran Reyniers, Marc Meyer, Evy Lobbestael, Daniela Stauffer, Bertran Gerrits, Lionel Muller, Sjouke Hoving, Klemens Kaupmann, Johannes Voshol, et al.
Pagina's: 2980 - 2992 - Indolinone based LRRK2 kinase inhibitors with a key hydrogen bond(2014)
Auteurs: Jean-Marc Taymans, Veerle Baekelandt
Pagina's: 4630 - 4637 - Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct cellular signaling pathways(2014)
Auteurs: Lauran Reyniers, Evy Lobbestael, Rita Derua, Etienne Waelkens, Veerle Baekelandt, Jean-Marc Taymans
Pagina's: 239 - 250 - In silico, in vitro and cellular analysis with a kinome-wide inhibitor panel correlates cellular LRRK2 dephosphorylation to inhibitor activity on LRRK2(2014)
Auteurs: Renée Vancraenenbroeck, Joren De Raeymaecker, Evy Lobbestael, Marc De Maeyer, Arnout Voet, Veerle Baekelandt, Jean-Marc Taymans
Pagina's: 51 - Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease(2014)
Auteurs: Evy Lobbestael, Veerle Baekelandt, Jean-Marc Taymans
Pagina's: 2626 - 2631 - In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants(2014)
Auteurs: Sarah Schreurs, Rita Derua, Etienne Waelkens, Jean-Marc Taymans, Veerle Baekelandt, Yves Engelborghs
Pagina's: 1040 - 1067 - A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation(2014)
Auteurs: Jean-Marc Taymans, Veerle Baekelandt
Pagina's: 895 - 908 - Regulation and targeting of enzymes mediating Parkinson's disease pathogenesis: focus on Parkinson's disease kinases, GTPases, and ATPases(2014)
Auteurs: Jean-Marc Taymans, Veerle Baekelandt
Pagina's: 71 - Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism(2014)
Auteurs: Jean-Marc Taymans, Veerle Baekelandt