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Onderzoeker
Leen Mathys
- Disciplines:Microbiologie, Systeembiologie, Laboratoriumgeneeskunde
Affiliaties
- Laboratorium Virologie en Chemotherapie (Rega Instituut) (Afdeling)
Lid
Vanaf1 okt 2011 → 30 sep 2015
Projecten
1 - 1 of 1
- Onderzoek naar de rol van de HIV enveloppe glycanen in de virale infectie en de antivrale activiteit van suiker-bindende moleculen.Vanaf29 sep 2011 → 30 sep 2015Financiering: FWO mandaten
Publicaties
1 - 8 van 8
- Tryptophan dendrimers that inhibit HIV replication, prevent virus entry and bind to the HIV envelope glycoproteins gp120 and gp41(2015)
Auteurs: Leen Mathys, Sam Noppen, Sandra Liekens, Jan Balzarini
Pagina's: 34 - 43 - Anti-HIV-1 activity of a tripodal receptor that recognizes mannose oligomers(2015)
Auteurs: Leen Mathys, Sam Noppen, Sandra Liekens, Jan Balzarini
Pagina's: 132 - 143 - HIV-1 envelope glycoproteins and their susceptibility as target for selective antiretroviral therapy(2015)
Auteurs: Leen Mathys, Jan Balzarini, Dominique Schols
- Several N-glycans on the HIV envelope glycoprotein gp120 preferentially locate near disulphide bridges and are required for efficient infectivity and virus transmission(2015)
Auteurs: Leen Mathys, Jan Balzarini
- The role of N -glycans of HIV-1 gp41 in virus infectivity and susceptibility to the suppressive effects of carbohydrate-binding agents(2014)
Auteurs: Leen Mathys, Jan Balzarini
Pagina's: 107 - Deletion of the highly conserved N-glycan at Asn260 of HIV-1 gp120 affects folding and lysosomal degradation of gp120, and results in loss of viral infectivity(2014)
Auteurs: Leen Mathys, Jan Balzarini
- Exposure of HIV-1 to a combination of two carbohydrate-binding agents markedly delays drug resistance development and selects for virus strains with compromised fitness(2014)
Auteurs: Leen Mathys, Jan Balzarini
Pagina's: 582 - 593 - Inhibition of infection and transmission of HIV-1 and lack of significant impact on the vaginal commensal lactobacilli by carbohydrate-binding agents(2013)
Auteurs: Mariya Petrova, Leen Mathys, Sarah Lebeer, Sam Noppen, Jos Vanderleyden, Jan Balzarini
Pagina's: 2026 - 2037